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KMID : 0379520050210010045
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한국독성학회지
2005 Volume.21 No. 1 p.45 ~ p.49
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Antioxidative Activity and Irritation Test of a Complex Herbal Bath Extracted from Korean Traditional Plants
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Chang Zhi-Qiang
Song Jae-Chan
Park Seung-Chun
Kim Jong-Choon
Lee Sam-Pin
Kim Young-Hoan
Lee In-Seon
KIm Nam-Woo
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Abstract
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The purpose of this study is to evaluate the free radical scavenging ability and xanthine oxidase inhibitory activity of a complex herbal bath consisted of Artemisiae argyi folium, Angelicae sinensis radix, Ligustici wallichii radix and Angelicae tuhuo radix, and its potential irritation response were also tested for safety use in the rabbits. For antioxidative activity, the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity of the complex herbal bath were examined at five different concentrations (0, 250, 500, 1000 and 2000 ㎍/ml). The concentration of the complex herbal bath required for scavenging DPPH free radical by 50% was 897.2 ㎍/ml. In the inhibition of xanthine oxidase (XO) activity, the concentration of the complex herbal bath required for 50% of inhibition was 221.4 ㎍/ml. In the skin irritation study in rabbit, all animals survived for the duration of the study and the examined skin exhibited no edema, erythema, and eschar formation. In the ocular irritation study in rabbit, after application of the sample to eyes, all of the eyes were normal. In summary, the complex herbal bath has potent antioxidant effects against the DPPH radical and XO and was considered to be a non-irritation bath for safety use.
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KEYWORD
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Antioxidative activity, Irritation, Herbal bath
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